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VLSI & Instrumentation
Neuropotential Interface
 Abstract
 
We have also fabricated a 16-channel electrophysiological interface chip in the same process for selective acquisition and digitization of any modality of neural signal. Each channel features a fixed gain bandpass amplifier with a tunable frequency response which allows isolation of the signal of interest, spikes, local field potentials (LFPs), electrocorticograms (ECoG), or electroencephalograms (EEG), without hardware modification and a programmable gain/resolution analog to digital converter (ADC). The bandpass amplifier analog front end has an input referred noise of 1.94 μVrms for a bandwidth of 8.2 kHz while drawing 12.2 μA of current from a 3.3 V supply.
Sub Topics
 
Micrograph of the 16-channel neuropotential acquisition chip along with EEG recording from a human subject.
 
Researchers
Mohsen Mollazadeh, MSE
Kartikeya Murari, MSE
 
Collaborators
Gert Cauwenberghs, PhD - University of California, San Diego
 
Funding
NIH 1R21MH074703-01A1
 
Publications
Mollazadeh M, Murari K, Cauwenberghs G, Thakor N, Micropower CMOS Low Noise Amplification, Filtering and Digitization of Multimodal Neuropotentials, IEEE Trans Biomed Circuits and Sys, 3(1):1-10, 2008

Mollazadeh M, Murari K, Schwerdt H, Wang X, Thakor NV, Wireless Multichannel Acquisition of Neuropotentials, Conf Proc IEEE Eng Med Biol Soc, 1:49-52, 2008

Mollazadeh M, Murari K, Cauwenberghs G, Thakor N, From Spikes to EEG: Integrated Multichannel and Selective Acquisition of Neuropotentials, Conf Proc IEEE Eng Med Biol Soc, 1:2741-44, 2008

Mollazadeh M, Murari K, Sauer C, Stanacevic M, Thakor N, Cauwenberghs G, Wireless Integrated Neurochemical and Neuropotential Sensing, in VLSI Circuits for Biomedical Applications, K. Iniewski (Ed), Artech House, Norwood, MA, pp. 1-26, 2008
 
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