Thakor Lab YouTube page
VLSI & Instrumentation
We have designed a 16-channel potentiostat for detection of electroactive neurotransmitters such as dopamine and nitric oxide. The chip was fabricated in AMI 0.5 μm CMOS process and can be interfaced to any sensor array. The core of the design is a first-order single bit delta-sigma modulator with programmable oversampling ratio. The modulation of feedback duty-cycle in modulator design enables choice of current range in accordance to magnitude and time constant of signal leading to current range that spans over six orders of magnitude and sensitivity up to picoamperes at hundred millisecond conversion time with power consumption of 300 μW.
Sub Topics
  Micrograph of the 16-channel wide range femtoampere sensitivity potentiostat along with in-vitro measurement of dopamine activity.
Kartikeya Murari, MSE
Christian Sauer, MSE
Gert Cauwenberghs, PhD - University of California, San Diego
NIH R21MH065296
Stanacevic M, Murari K, Rege A, Cauwenberghs G, Thakor N, VLSI Potenstiostat Array with Oversampling Gain Modulation for Wide-Range Neurotransmitter Sensing, IEEE Trans Biomed Circuits and Sys, 12(1):63-72, 2007

Murari K, Stanacevic M, Cauwenberghs G, Thakor NV, Integrated potentiostat for neurotransmitter sensing, IEEE Eng Med Biol Mag, 24(6):23-9, 2005
Go to Top

Copyright © 2008 JHU Neuroengineering & Biomedical Instrumentation Lab
All rights reserved.