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VLSI & Instrumentation
Potentiostat
 Abstract
 
We have designed a 16-channel potentiostat for detection of electroactive neurotransmitters such as dopamine and nitric oxide. The chip was fabricated in AMI 0.5 μm CMOS process and can be interfaced to any sensor array. The core of the design is a first-order single bit delta-sigma modulator with programmable oversampling ratio. The modulation of feedback duty-cycle in modulator design enables choice of current range in accordance to magnitude and time constant of signal leading to current range that spans over six orders of magnitude and sensitivity up to picoamperes at hundred millisecond conversion time with power consumption of 300 μW.
Sub Topics
 
  Micrograph of the 16-channel wide range femtoampere sensitivity potentiostat along with in-vitro measurement of dopamine activity.
 
Researchers
Kartikeya Murari, MSE
Christian Sauer, MSE
 
Collaborators
Gert Cauwenberghs, PhD - University of California, San Diego
 
Funding
NIH R21MH065296
 
Publications
Stanacevic M, Murari K, Rege A, Cauwenberghs G, Thakor N, VLSI Potenstiostat Array with Oversampling Gain Modulation for Wide-Range Neurotransmitter Sensing, IEEE Trans Biomed Circuits and Sys, 12(1):63-72, 2007

Murari K, Stanacevic M, Cauwenberghs G, Thakor NV, Integrated potentiostat for neurotransmitter sensing, IEEE Eng Med Biol Mag, 24(6):23-9, 2005
 
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